Current Studies

ACCOMPLISH TRIAL (High Blood Pressure)

Inclusion:

Exclusion:

Benefits of participation in the study:

$25.00 per scheduled visit completed ($250.00 for total of 11 visits over 3 to 4 years)
Free study medication, study related lab work, ECG's and physical exams

If you are interested in this study contact Pam Trenkamp,
Study Coordinator, at 319-272-2523

Gallant 6 (Type II Diabetes) ˆtop

Inclusion:

Men or women ages 18 years or older
HbA1c ≥ 7% for drug naïve patients and ≤ 10% for all patients at visit 1
Diagnosed with type 2 diabetes
Treated with diet alone or treatment with single oral agent or low doses of two agents

Exclusion:

Type 1 diabetes, history of diabetic ketoacidosis, or corticosteroid-induced type 2 diabetes
NYHA heart failure Class III or IV, or unstable Class I or II
History of thyroid ophthalmopathy
History of malignancy within the last 5 years, excluding successful treatment of basal or squamous cell skin carcinoma

Benefits of participation in the study:

$25.00 per scheduled visit completed ($325.00 for total of 13 visits in 36 weeks )
Free study medication, study related lab work, EKGs and physicals

If you are interested in this study contact Angie Bixby-Ellermann, Study Coordinator, at 319-272-2536

LAF 237 (Diabetes- Type II) ˆtop

Inclusion:

Male or female ages 18-80 years
Patient who have received sulfonylurea for at least three months and have been on a stable dose (at least 7.5 mg glyburide qd, at least 7.5 mg glipizide qd or at least 2 mg glimepiride qd) for at least 4 weeks prior to visit 1 Patients not already treated with glimepiride 4 mg qd must be willing to switch to that drug and dose at visit 1
Body mass index (BMI) in the range of 22-45 kg/m2 inclusive at visit 1
HbA1c in the range of 7.5 to 11% inclusive at visit 1

Exclusion:

A history of:
1. Type 1 diabetes, diabetes that is a result of pancreatic injury, or secondary forms of diabetes, e.g., Cushing’s syndrome and acromegaly
2. Acute metabolic diabetic complication such as ketoacidosis or hyperosmolar state (coma) within the past 6 months
Congestive heart failure NYHA class III or IV.
Malignancy including leukemia and lymphoma (not including basal cell skin cancer) within the last 5 years.
Liver disease such as cirrhosis or chromic active hepatitis
Known sensitivity to glimepiride

Benefits of participation in the study:

$25.00 per scheduled visit completed ($150.00 for total of 6 visits although there is a possibility of an extention with additional scheduled visits)
Free study medication, study related lab work, EKGs and physicals

If you are interested in this study contact Angie Bixby-Ellermann, Study Coordinator, at 319-272-2536

Madeitt (Metabolic Syndrome) ˆtop

Inclusion:

Male or female 18 to 75 years of age
Central obesity defined as: Males with a waist circumference of > 40 inches and Female with a waist circumference of > 35 inches
The average mean BP from visit 2 and visit 3 must meet the following blood pressure criteria: MSSBP of ≥ 130 mmHg but ≤ 160 mmHG and a MSDBP of ≥ 85 mmHg but ≤ 100 mmHg
At least of of the following criteria:
1. Fasting plasma glucose between 5.6 and 6.9 mmol/l based on result of FPG drawn at visit 2
2. Serum triglycerides > 150 mg/dL
3. Serum HDL cholesterol < 40 mg/dL in males or serum HDL cholesterol <50 mg/dL in females

Exclusion:

Patients who have been taking a diuretic for 3 months prior to visit 1
Patients with a history of diabetes
History of stroke, TIA, or MI
Active and or treated malignancies within 12 months prior to visit 1 with the exception of basal cell or squamous cell carcinoma

Benefits of participation in the study:

If you are interested in this study contact Angie Bixby-Ellermann, Study Coordinator, at 319-272-2536

PRoFESS study (Prevention of second stroke) ˆtop

Inclusion:

History of ischemic stroke (lack of blood supply to the brain) within the last three months
Patients must be 55 years of age or older

Exclusion:

Hemorrhagic stroke (bleeding in the brain)
Current congestive heart failure
Known brain tumor
History of dementia
Stroke associated with a cardiovascular surgical procedure (carotid endarterectomy, angiogram or heart surgery)
Any history of kidney or liver problems
Active peptic ulcer disease (heartburn)
History of heart attack or angina (chest pain) within the last three months

Benefits of participation in the study:

$25.00 per scheduled visit completed ($250.00 for total of 11 visits over 4 year period)
Free study medication, study related lab work

If you are interested in this study contact Pam Trenkamp, Study Coordinator, at 319-272-2523